Available positions

ESR03

WP2. Optimization of acid-sensing ion channels for sustained pH sensing.

Recruiting institution: University of Lausanne

Location: Lausanne, Switzerland

Supervisors: Stephan Kellenberger, Ivan Gautschi

Project description:

The project involves mutagenesis of acid-sensing ion channels to produce a sustained response to pH changes, electrophysiological characterization of these mutants, and expression as fusion protein and biochemical purification of selected mutants.

Secondments:

  1. École Polytechnique Fédérale de Lausanne (Switzerland). Protein expression and purification.

  2. University of Warsaw (Poland). Electrical properties measurements on planar lipid bilayers with ion channels.

PhD awarding entity: University of Lausanne

Qualifications: Those beside of the generall call.

Skills: Practical knowledge of molecular biology techniques, electrophysiology and biochemistry of proteins will be an advantage.

Experience: Those beside of the general call.

Expected start day: September-October, 2021